| Fig.1. Scanning electron micrograph of Yersinia pestis bacteria mass in foregut of a flea (Credit: Rocky Mountain Laboratories, NIAID, 2010) |
Since the beginning of the year, fifteen people in the United States have been infected with the bubonic plague, and four of those individuals have died. This disease, often only mentioned in context of the Black Death (1346-1353 AD) or the Justinian Plague (541-542 AD), still exists today in pockets around the world. The causative pathogen Yersinia pestis hides in natural reservoirs, such as black-tailed prairie dogs in the southwestern United States or marmots in the Eurasian Steppe, only to flare up in human populations when rodents and the fleas they carry get too close.
Despite the deadly history of the disease - the Black Death killed an estimated 60 percent of the European population - Y. pestis evolved from a much less virulent ancestor that caused symptoms closer to the common cold. Previous research pinpointed the first appearance of this bacterium in skeletal remains at 1,500 years ago, but a study released last week in the journal Cell pushes that date back to more than 5,000 years ago.

